Revista de Medicina Interna. AMICAC.


Año VII. 2015 No.8

Mes Agosto 2015

Borrelia miyamotoi Disease in the Northeastern United States A Case Series. Philip J. Molloy, MD; Sam R. Telford III, ScD; Hanumara Ram Chowdri, MD; Timothy J. Lepore, MD; Joseph L. Gugliotta, MD; Karen E. Weeks, BS; Mary Ellen Hewins, BS; Heidi K. Goethert, ScD; and Victor P. Berardi.
The first recognized cases of Borrelia miyamotoi disease (BMD) in North America were reported in the northeastern United States in 2013. Among 11 515 patients tested, 97 BMD cases were identified by PCR. Most of the 51 case patients on whom clinical histories were reviewed presented with high fever, chills, marked headache, and myalgia or........

PCSK9 Inhibitors: A New Era in Lipid-Lowering Treatment?.
In 2003, mutations in the gene encoding the enzyme proprotein convertase subtilisin/kexin type 9 (PCSK9) were identified as genetic causes for familial hypercholesterolemia (1). Investigations soon showed that PCSK9 was a key regulator of low-density lipoprotein (LDL) cholesterol metabolism that promoted the hepatic degradation of LDL receptors and reduced the liver's ability to remove circulating LDL cholesterol. The subsequent characterization of loss-of-function mutations in PCSK9 that result in..............

Effect of Allowing Choice of Diet on Weight Loss A Randomized Trial William S. Yancy Jr., MD; Stephanie B. Mayer, MD; Cynthia J. Coffman, PhD; Valerie A. Smith, DrPH; Ronette L. Kolotkin, PhD; Paula J. Geiselman, PhD; Megan A. McVay, PhD; Eugene Z. Oddone, MD; and Corrine I. Voils, PhD.
Choosing a diet rather than being prescribed one could improve weight loss.Of 105 choice participants, 61 (58%) chose the LCD and 44 (42%) chose the LFD; 5 (3 on the LCD and 2 on the LFD) switched diets at 12 weeks, and 87 (83%) completed measurements at 48 weeks. Of 102 comparator participants, 53 (52%) were randomly assigned to the LCD and 49 (48%) were assigned
to the LFD; 88 (86%) completed................